Allo-hematopoietic stem cell transplantation is a potential treatment for a patient with a combined disorder of hereditary spherocytosis.
- Author:
Xiao-hui ZHANG
1
;
Hai-xia FU
;
Lan-ping XU
;
Dai-hong LIU
;
Huan CHEN
;
Wei HAN
;
Yu-hong CHEN
;
Feng-rong WANG
;
Jing-zhi WANG
;
Yu WANG
;
Ting ZHAO
;
Kai-yan LIU
;
Xiao-jun HUANG
Author Information
1. Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China.
- Publication Type:Case Reports
- MeSH:
Adult;
Female;
Hematopoietic Stem Cell Transplantation;
Humans;
Spherocytosis, Hereditary;
therapy;
Transplantation, Homologous
- From:
Chinese Medical Journal
2012;125(5):947-950
- CountryChina
- Language:English
-
Abstract:
Both human hereditary spherocytosis (HS) and chronic myelogenous leukemia (CML) are life threatening. Herein we have reported the case of a woman with a combined disorder of HS and CML who underwent the matched sibling allogeneic stem cell transplantation. The complete donor erythroid cells were obtained. The red blood cell counts significantly improved throughout life comparing with pre-hematopoietic stem cell transplantation (HSCT). Reticulocyte counts normalized, and BCR-ABL was cleared away. The total bilirubin level was also corrected in this recipient. Our case is a rare example with a combined disorder of HS and CML following allogeneic stem cell transplantation. HS was not a contraindication for patient in the matched sibling transplant setting.
