Study on the association of oral contraceptives, angiotensin-converting enzyme gene polymorphisms and risk of stroke in women
10.3760/cma.j.issn.0254-6450.2012.01.005
- VernacularTitle:口服避孕药及血管紧张素转化酶基因多态性与女性脑卒中发病风险的关系
- Author:
Hui-Qiao LI
1
;
Ing Y LI
;
Chun WANG
;
Tao SUN
;
Zhi-Ming SUN
;
Jian ZHOU
;
Lei BA
;
Zhi-Zheng HUANG
Author Information
1. 南京医科大学
- Keywords:
Stroke;
Oral contraceptives;
Angiotensin-converting enzyme;
Gene polymorphisms
- From:
Chinese Journal of Epidemiology
2012;33(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the associations of oral contraceptives (OC) exposure,angiotensin-converting enzyme(ACE) gene polymorphism and their joint actions with the risk of stroke in Chinese women.Methods A case-control study,based on a set cohort,was carried out.Incident cases of stroke identified between July 1 1997 and June 30 2009 were enrolled.One hospital control and healthy community control were matched on region and age ( ± 3 years).A total of 453women with stroke and 919 controls were recruited.I/D genepolymorphism was detected by polymerase chain reaction (PCR) and amplification fragment length polymorphism (AFLP),A-240T polymorphism were detected by TagMan.Results ( 1 ) The risk of stroke gradually increased with the cumulative time of OC being used in women (P＜0.0001).Compared with non-users,the risk of stroke significantly increased among those with cumulative time of using OC longer than 20 years (adjusted OR was 2.07,with 95％ CI as 1.30-3.29).(2) ID/DD genotype of I/D locus indicated significantly an increased risk of hemorrhagic stroke (adjusted OR,2.37; 95％CI,1.46-3.84).(3)Women with ID/DD genotype of I/D locus or with TA/TT genotype of A-240T locus and using OC could significantly increase the risk of hemorrhagic stroke (adjusted OR was 4.59; with 95％ CI as 2.21-9.51 and OR was 2.50; with 95％CI as 1.42-4.38).(4) Data from multivariate analyses showed that both OC and ID/DD genotypes were important risk factors for hemorrhagic stroke.Conclusion ID/DD and TA/TT genotypes of ACE gene,OC and their joint action might increase the risk of stroke,especially on hemorrhagic stroke in Chinese women.
