Association between urinary albumin-to-creatinine ratio and prehypertension
10.3760/cma.j.issn.0254-6450.2012.01.007
- VernacularTitle:晨尿中微量白蛋白/肌酐比值与中老年女性高血压前期关系的研究
- Author:
Qiu ZHANG
1
;
Hao PENG
;
Jian-Song DING
;
Yan-Ying XU
;
Xiang-Qin CHAO
;
Hong-Gang TIAN
;
Yong-Hong ZHANG
Author Information
1. 苏州大学医学部
- Keywords:
Hypertension;
Prehypertension;
Urinary albumin-to-ereatinine ratio
- From:Chinese Journal of Epidemiology
2012;33(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was operated to investigate the association between urinary albumin-to-creatinine ratio (UACR) and physical situations as hypertension and prehypertension among women.Methods Blood pressure,height,weight and waist circumference were measured and factors such as cigarette smoking,alcohol intake,family history of hypertension,were investigated.Blood glucose and lipid,serum uric acid,urinary albumin and urinary creatinine were tested on 1796 women aged ≥30 years living in the Jinchang district of Suzhou.Associations between UACR and hypertension as well as prehypertension were analyzed,by using ordinal multinomial logistic regression models.Results The mean levels of UACR were 15.54 (7.67,32.53),9.01 ( 5.45,18.06),7.13 (4.60,12.50 ) mg/g and the rates of higher UACR were 27.57％,13.42％,9.61％ in hypertensive,pre-hypertensive and normotensive subjects,respectively,with significant differences noticed among the three groups (P＜0.05).The average systolic blood pressure/diastolic blood pressure appeared to be 125.3/80.9,128.8/82.7,130.8/84.0 and 135.1/85.9 mm Hg for participants with UACR in the first,second,third and fourth quartile,respectively.The risks of prehypertension or hypertension increased with increasing UACR levels.Dose-response relationship was seen between UACR and risks of prehypertension or hypertension.Multivariable adjusted odds ratios (95％CI) of prehypertension or hypertension in the upper quartiles of UACR were 1.32 ( 1.02,1.70),1.72 ( 1.32,2.24),and 2.37 (1.80,3.11 ),respectively,when compared with the lowest quartile.Conclusion Elevated UACR was associated with both hypertension and prehypertension among women.
