Survey on the transmission of HIV drug resistance in Kunming, Yunnan province in 2010
10.3760/cma.j.issn.0254-6450.2012.01.017
- VernacularTitle:昆明市2010年HIV-1耐药传播警戒线调查
- Author:
Min CHEN
1
;
Yan-Ling MA
;
Cheng-Xia CHU
;
Hui XING
;
Yan-Sheng XU
;
Ying-Zhen SU
;
Ying YANG
;
Hui-Chao CHEN
;
Hong-Bing LUO
;
Man-Hong JIA
;
Lin LU
Author Information
1. 云南省疾病预防控制中心
- Keywords:
Human immunodeficiency virus;
Drug resistance transmission threshold survey;
Antiretroviral therapy
- From:
Chinese Journal of Epidemiology
2012;33(1):75-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the HIV drug resistance (HIVDR) transmission in Kunming city of Yunnan province in 2010.Methods Referring to the guidelines for HIV drug resistance threshold survey (HIVDR-TS) set by WHO,62 plasma samples of recently reported HIV-infected individuals who were older than 25 years of age,were collected from January to August 2010.Genotyping of pol genetic mutations associated with HIVDR with reverse transcriptional PCR was performed and the prevalence of HIV-1 drug resistance transmission was evaluated.Results Of the 62 plasma samples,54 were successfully sequenced and genotyped on pol sequence.Based on the pol sequences,HIV subtypes including CRF08_BC ( 53.2％ ),CRF07_BC ( 25.5％ ),CRF01_AE ( 19.1％ )and C (2.1％) were identified.According to the time of sampling,the first 47 sequenced samples were used for drug resistance prevalence analysis.A protease inhibitor (PI) relative mutation was found in one sample.Based on the WHO standard,the prevalence of transmitted HIV-1 drug resistance was ＜5％.Conclusion HIV-1 drug resistant strains transmission was still catalogued as low prevalence level in Kunming.To prevent the increase of HIVDR prevalence,normative treatment and scientific management to AIDS patients seemed to be quite important.
