Relationship between serum visfatin level and children and adolescent obesity and non-alcoholic fatty liver disease
10.3760/cma.j.issn.0254-6450.2012.03.005
- VernacularTitle:内肥素与儿童青少年肥胖、非酒精性脂肪肝的关联研究
- Author:
Han WEN
1
;
Hai-Jun WANG
;
Bin DONG
;
Jun MA
Author Information
1. 北京大学
- Keywords:
Visfatin;
Obesity;
Fatty liver;
Child
- From:
Chinese Journal of Epidemiology
2012;33(3):269-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the relationships between the level of serum visfatin and obesity,nonalcoholic fatty liver disease (NAFLD)in children and adolescents. Methods Serum visfatin levels of 106 obese children/adolescents (including 49 non-NAFLD children and adolescents and 57 NAFLD children/adolescents in which consisting of 42 mild ones,15 moderate-to-severe ones)with another 69 lean children/adolescents as their controls,were examined by indirect sandwich ELISA.Results When comparing the serum visfatin levels,there was no significant difference noticed between the obese group ( 1.71 ± 0.37) ng/ml and the lean group ( 1.75 ± 0.37) ng/ml (P=0.455).With the severity of NAFLD,the serum visfatin level showed an elevation in obese children and adolescents [ obese without NAFLD ( 1.59 ± 0.36) ng/ml,obese with mild NAFLD ( 1.74 ± 0.36) ng/ml,obese with moderate-to-severe NAFLD (1.97 ± 0.36) ng/ml,P＜0.05].In the obese group,serum visfatin levels seemed to be related to age (^β=-0.326,P=0.000),alanine aminotransferase (ALT) (^β =0.286,P=0.004) and the degree of NAFLD (^β =0.246,P＝0.014).Conclusion The level of serum visfatin was related to non-alcoholic fatty liver in obese children and adolescent.
