Long term epidemiological effects of vaccination on hemorrhagical fever with renal syndrome (HFRS) in Shaanxi provincial HFRS epidemic areas
10.3760/cma.j.issn.0254-6450.2012.03.014
- VernacularTitle:陕西省肾综合征出血热疫区人群国产疫苗免疫远期效果分析
- Author:
Jing-Jun WANG
1
;
Zhan-Zhen WEI
;
Jing WEI
;
Chang-An MA
;
Jian-Hua DONG
;
Xiao-Ling LU
;
Yuan ZHENG
;
Peng-Bo YU
;
Jian-Hui QU
;
Li-Fang DONG
Author Information
1. 陕西省疾病预防控制中心
- Keywords:
Hemorrhagical fever with renal syndrome vaccination;
Antibody;
Protective rate
- From:
Chinese Journal of Epidemiology
2012;33(3):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective rate and the variation of HFRS-IgG on hemorrhagical fever with renal syndrome (HFRS) vaccine.Methods Cluster,random sampling and cross-sectional study were used to assess the protective rate of HFRS vaccination.Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS.Results Curve equation was obtained as Yprocective rate=(0.863+0.283/Xvaccination term) × 100％ by protective rate with vaccination term.Protective rates showed a reducing trend,90％ after 7-8 years of vaccination,88％ after 10 years,and 94％ on average.Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without,in the epidemic area.Higher antibody level could be obtained after primary vaccination,but the level of antibody had a 50％ reduction after 5-10 years of vaccination,and a 60％ reduction after 10 years of vaccination.Conclusion HFRS antibody had a 50％ reduction after 5-10 years of vaccination.The protective rate of HFRS vaccination had a 90％ loss,after 7-8 years of vaccination.Booster dose was necessary after 7 years of vaccination.
