Application of log-linear model in the case-parent triad study

VernacularTitle:对数线性模型在病例-父母对照研究中的应用
Author: Ming ZHU ¹ ; Shao-Fa NIE ; Wei-Rong YAN
Author Information

1. 华中科技大学同济医学院
Keywords: Case-parent triad; Log-linear model; Gene polymorphisms; Maternal-fetal interaction
From: Chinese Journal of Epidemiology 2012;33(4):435-438
CountryChina
Language:Chinese
Abstract: We were introducing a log-linear model for case-parent triad study.Data from a previous study of the association between MTHFR C677T aud cleft lip with or without cleft palate (CL/P) was analyzed,in order to investigate the maternal effect,fetal effect and their interaction,using a series of log-linear models.Our results showed that mothers who were carrying two copies of MTHFR C677T variant alleles appeared to have reduced the risk of CL/P in offspring,comparing to those with homozygous of wild-type allele.With S2=0.43 (95％ CI:0.19-0.95).No significant association was found for fetal genotype and maternal-fetal iuteraction with CL/P.Log-linear model method seemed to be useful in the estimation of maternal effect,fetal effect and maternal-fetal interaction,in the case-parent triad study design.This approach showed specific benefit in studies that related to genetic effects on complex diseases such as pregnancy complications and diseases originated from fetus.