Experimental study on treatment of immune ulcerative colitis in mice by Changlu Enema.
- Author:
Yao-nan WU
1
;
Yu-qin XIAO
;
Yi-bin CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Rectal; Animals; Colitis, Ulcerative; drug therapy; immunology; Colon; drug effects; pathology; Drugs, Chinese Herbal; administration & dosage; therapeutic use; Male; Mice; Phytotherapy; Random Allocation; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(1):65-68
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutic effect of Chinese compound, Changlu Enema (CE), on immune ulcerative colitis (UC) in mice.
METHODSMice were randomly divided into the normal group, the model group, the CE high dose (CE-H) and low dose (CE-L) group and the salicylazosulfapyridine (SASP) group. All mice, except those in the normal group, were made into UC model by colonic mucosa protein immunization. After 21 days of medication, the changes of UC activity index and body weight in mice were observed, and the condition of colonic inflammation and histomorphological changes in colonic tissue were observed also.
RESULTSUC activity index was lower and body weight was higher in the two CE groups than those in the model group respectively, showing significant difference (P < 0.05 or P < 0.01); pathological examination showed the pathological changes and inflammatory response in colonic tissue were relieved significantly after treatment, and the improvement in the CE-H group was better than that in the SASP group.
CONCLUSIONTCM compound CE is markedly effective in treating UC rats.
