Effect of clearing heat and removing dampness method on formation of pigment gallstones in rabbits.
- Author:
Xi-bo ZHANG
1
;
Nai-qiang CUI
;
Dong-hua LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bile; drug effects; metabolism; Bile Pigments; metabolism; Calcium; metabolism; Drugs, Chinese Herbal; therapeutic use; Female; Gallstones; drug therapy; metabolism; pathology; Glucuronidase; metabolism; Male; Phytotherapy; Rabbits; Random Allocation; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(3):241-243
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe dynamically the effect of drugs for clearing heat and removing dampness (CHRD) on biliary components in rabbits with pigment gallstones (PGS).
METHODSForty rabbits were established into PGS model and randomly divided into 3 groups, the bacterial infection group, the CHRD low-dose group and the CHRD high-dose group. Besides, a normal group was set up with healthy rabbits for control. Changes of total bilirubin (TB), unconjugated bilirubin (UCB), total bile acid (TBA), Ca2+, bacterial and endogenous beta-glucuronidase (beta-Gase) in bile were observed.
RESULTSCHRD drugs significantly decreased the contents of UCB, Ca2+, bacterial and endogenous beta-Gase (P < 0.05), and increased TBA in bile (P < 0.05).
CONCLUSIONCHRD drugs have good effect in reducing the lithogenesis of the pigment gallstones.
