Experimental study on effect of Shenling Yigan Granule in antagonizing duck hepatitis B virus.
- Author:
Hong-quan ZHANG
1
;
Hui GE
;
Xin LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antiviral Agents; pharmacology; therapeutic use; Drugs, Chinese Herbal; pharmacology; therapeutic use; Ducks; Hepadnaviridae Infections; drug therapy; Hepatitis B Virus, Duck; drug effects; Hepatitis, Viral, Animal; drug therapy; Phytotherapy; Random Allocation
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(3):244-246
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the viral inhibitory effect of Shenling Yigan Granule (SYG) on duck hepatitis B virus (DHBV) in vivo.
METHODSChongqing ducks infected with DHBV were used. They were randomly divided into five groups, the small-, medium- and high-dose (1.6 g/kg, 3.2 g/kg, 6.4 g g/kg) SYG groups, the lamivudine positive control group, and the model group. The changes of serum DHBV-DNA, DHB-sAg contents and hepatic pathology were observed.
RESULTSThe serum content of DHBV-DNA in the three SYG groups and the positive control group was significantly decreased (P < 0.05), while it was rebounded in the latter at day 7 after stopped lamivudine administration. The change of DHBsAg level was insignificantly in all groups. And the hepatic pathological change in the SYG groups and positive control group was slighter than that in the model control group, but showed insignificant difference in comparison between the SYG groups and the model group (P > 0.05).
CONCLUSIONSYG has certain in vivo inhibitory effects on DHBV-DNA.
