Effects of Ginkgo biloba extract (ginaton) on mRNA expression of bcl-2 and bcl-xL in myocardium of patients underwent hypothermic cardiopulmonary bypass.
- Author:
Yun-kun DENG
1
;
Fang WEI
;
Yong-nian LI
Author Information
- Publication Type:Journal Article
- MeSH: Cardiopulmonary Bypass; methods; Child; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Gene Expression; drug effects; Ginkgo biloba; chemistry; Heart Defects, Congenital; genetics; surgery; Humans; Hypothermia, Induced; Male; Myocardium; cytology; metabolism; Plant Leaves; chemistry; Proto-Oncogene Proteins c-bcl-2; genetics; RNA, Messenger; genetics; metabolism; Reverse Transcriptase Polymerase Chain Reaction; bcl-X Protein; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(3):256-258
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Ginkgo biloba extract (Ginaton) on bcl-2 and bcl-xL mRNA expression in the myocardium of patients underwent hypothermic cardiopulmonary bypass (CPB).
METHODSThirty congenital heart disease patients were randomly assigned to 2 groups, the control group and the treated group. Patients in both groups received St. Thomas' cardioplegic solution via radix aortae, while Ginaton (0.5 mg/kg) was added in the treated group. Cardiac surgery was started after complete heart arrest. Myocardium was taken before the aorta ascendens was unblocked and mRNA expression of bcl-2 and bcl-xL in the ventricular tissue was detected by RT-PCR.
RESULTSThe gene expressions of bcl-2 and bcl-xL were significantly higher in the treated group than those in the control group (P < 0.05).
CONCLUSIONGinaton could promote the mRNA expressions of the antiapoptotic gene bcl-2 and bcl-xL in myocardium of patients underwent CI'PB.
