Application of TC index location on Longa' s animal model of regional experimental cerebral ischemia and reperfusion.
- Author:
Zhong-ren LI
1
;
Long CUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; pathology; Carotid Arteries; pathology; Disease Models, Animal; Incisor; pathology; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; pathology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26 Suppl():18-20
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the TC index location on a reform LONGA' s animal model of regional experimental cerebral ischemia and reperfusion.
METHODSA total of 300 SD male rats were randomly divided into the pre-test group (n = 30), the original method group (n = 120, Longa' s method) and the reform method group [ n = 150, TC index location is defined by the length of rat incisor teeth root (T point) to the common carotid artery bifurcation (C point) ,the blood flow of a unilateral middle cerebral artery in the rats was reversibly blocked by the TC index location). The morphologic changes and the successful rate of the two methods to establish the rat model were compared.
RESULTSThe successful rate of TC index location modified model method was superior to that of original LONGA' s method,with significant difference in linear correlation analysis.
CONCLUSIONThe reform LONGA' s animal model of regional experimental cerebral ischemia and reperfusion by the TC index location is a good method, and is worth applying in experimental study.
