Study on the pharmacological mechanism of analgesic effect of injection stauntoniae.
- Author:
Su CHEN
1
;
Xiang-ming LIU
;
Fan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Analgesics; administration & dosage; pharmacology; Animals; Drugs, Chinese Herbal; administration & dosage; pharmacology; Ferns; Ganglia, Spinal; drug effects; metabolism; Injections; Neurons; drug effects; metabolism; Rats; Sodium Channels; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26 Suppl():39-43
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of Injection Stauntoniae (IS) on voltage-gated sodium currents in dorsal root ganglion neurons and analyze its pharmacological mechanism of blocking the nerve conduction and anal gesic action.
METHODSWhole-cell patch-clamp recordings were performed in acutely isolated rat dorsal root ganglion neurons and the effects of 10% , 25% and 50 % IS on voltage-gated sodium currents were observed.
RESULTSIS inhibited the peak sodium currents in dorsal root ganglion neurons in a dose-dependent way and affected the activation and inactivation process of the channels.
CONCLUSIONThe analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.
