Exogenous 3', 5'-cyclic diguanylic acid prevents caries formation in rats.
- Author:
Wenjuan YAN
1
;
Dehong YANG
;
Buling WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclic GMP; analogs & derivatives; therapeutic use; Dental Caries; microbiology; prevention & control; Disease Models, Animal; Female; Rats; Streptococcus mutans
- From: Journal of Southern Medical University 2012;32(5):639-642
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of exogenous c-di-GMP in preventing dental caries formation in SD rats.
METHODSTwenty-day-old SD rats with dental caries induced by S. Mutans infection were randomly divided into 3 groups for treatment with dental application of exogenous c-di-GMP, NaF solution or 0.9% NaCl, and changes in the bacterial number and scores of dental caries following the treatments were recorded.
RESULTSCompared with 0.9% NaCl treatment, exogenous c-di-GMP treatment significantly lowered the scores of dental caries on the occlusal surface and smooth surface (P<0.05) but produced no obvious effect on the number of bacterial plagues (P>0.05).
CONCLUSIONExogenous c-di-GMP can be a novel agent for prevention and treatment of tooth decay.
