Efficacy of antioxidants in treatment of nonalcoholic fatty liver: a systematic review.
- Author:
Mingxi ZENG
1
;
Yiping WANG
;
Liping WU
Author Information
- Publication Type:Journal Article
- MeSH: Antioxidants; therapeutic use; Fatty Liver; drug therapy; Humans; Non-alcoholic Fatty Liver Disease; Randomized Controlled Trials as Topic; Treatment Outcome
- From: Journal of Southern Medical University 2012;32(5):695-702
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of antioxidants in the treatment of non-alcoholic fatty liver.
METHODSThe Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE or PUBMED (1978-2011), EMBASE (1978-2011), ISI, OVID Database (1978-2011), CNKI Net and WANFANG database (1978-2011) were searched for relevant randomized controlled trials, with also manual search of the bibliographies of the retrieved articles. The data were synthesized to assess the histological response of the patients (hepatic steatosis, inflammation and fibrosis) and hepatic biochemical changes after the treatments (alanine aminotransferase responses).
RESULTSFourteen trials involving 1284 patients were included in the Meta-analysis. The quality of the trials was inconsistent. The data were extracted for meta-analysis or descriptive analysis, which did not yield sufficient evidence that antioxidants could improve hepatic steatosis, inflammation, fibrosis or alanine aminotransferase responses.
CONCLUSIONSThe current data do not support a positive therapeutic effect of antioxidants on nonalcoholic fatty liver, and antioxidants are therefore not recommended in the clinical treatment of the condition.
