Preliminary identification to the correlation between anti\u2013CCP2 antibodies and some factors in rheumatoid arthritis
- Author:
Lan Thi Ngoc Nguyen
;
Mai Thi Thanh Nguyen
;
Ngoc Vinh Nguyen
- Publication Type:Journal Article
- Keywords:
anti \ufffd?CCP2 antibodies;
rheumatoid arthritis;
sensitivity
- MeSH:
Arthritis;
Rheumatoid/ pathology;
epidemiology;
Antibodies/ adverse effects
- From:Journal of Medical Research
2007;47(2):57-63
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and deformity of the joints. Objectives: The study have two purposes: (1) Identify the sensitivity of anti - CCP2 antibodies in rheumatoid arthritis. (2) Identify the correlation between anti - CCP2 antibodies and clinical manifestations, laboratory features of rheumatoid arthritis. Subjects and method: The study was carried out on 70 patients with rheumatoid arthritis from March to July 2006 in rheumatology department at Bach Mai hospital. All they were diagnosed according to the criteria of American College of Rheumatology 1987. Results: Results of study showed that: (1) The sensitivity of anti - CCP2 antibodies is 67.1% (2) The sensitivity of anti - CCP2 antibodies in patients with rheumatoid arthritis is 67.1 % and is as high as the sensitivity of rheumatoid factor. In early stage of disease (the duration of disease under 12 months) the sensitivity of anti - CCP2 antibodies is higher than rheumatoid factor (70% versus 57.5%). There are no significant differences between the group having anti - CCP2 antibodies and the group who did not have anti - CCP2 anti- bodies in any stages of disease about Ritchie index, DAS - 28 index, X - rays, erythrocyte sedimentation rate in the first hour, CRP ratio. Conclusions: The sensitivity of anti - CCP2 antibodies in patients with rheumatoid arthritis is 67.1 %. There is the relation between anti - CCP2 antibodies and the severity of the inflammation and the severity of X - rays.
