Expression of TMEM16A in gastric carcinoma and its clinical implications.
- Author:
Jun YANG
1
;
Ni LIU
;
Anjing KANG
;
Yaofeng JIN
;
Junning WANG
;
Baoshan SU
;
Xiaoli CHEN
;
Zongfang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Anoctamin-1; Carcinoma; metabolism; pathology; Chloride Channels; metabolism; Female; Humans; Male; Middle Aged; Neoplasm Proteins; metabolism; Stomach Neoplasms; metabolism; pathology
- From: Journal of Southern Medical University 2012;32(6):794-797
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of TMEM16A in gastric carcinoma and its clinical implications.
METHODSA total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.
RESULTSTMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).
CONCLUSIONAberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.
