Organ-protective effect of continuous renal replacement therapy in a patient with severe polymyositis and dermatomyositis.
- Author:
Zhanguo LIU
1
;
Jian ZHOU
;
Zhongran CEN
;
Ying TANG
;
Xiangrui YANG
;
Ping CHANG
Author Information
1. Department of ICU, Zhujiang Hospital, Southern Medical University, Guangzhou, China. xueshengcom@yahoo.com.cn
- Publication Type:Case Reports
- MeSH:
Adult;
Dermatomyositis;
therapy;
Humans;
Male;
Polymyositis;
therapy;
Renal Replacement Therapy;
Treatment Outcome
- From:
Journal of Southern Medical University
2012;32(6):854-856
- CountryChina
- Language:Chinese
-
Abstract:
A patient with skin rash, skin denudation, anuria, general dropsy and dyspnea for unknown etiology underwent continuous renal replacement therapy (CRRT) for 3 consecutive days. The biochemical indexes were monitored during the therapy and biopsy was performed on the right thigh. Pathological examination of the biopsy sample established the diagnosis of polymyositis(PM) and dermatomyositis(DM). After the start of CRRT, the patient's heart, liver, kidney and lung injuries showed obvious improvement, and the urine volume (UV) increased and serum creatinine (Cr), urea, total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and lactate dehydrogenase (LDH) levels all decreased promptly. The patient showed progressive improvement of the physiological condition even after CRRT, and was discharged 10 days later. This case suggests the efficacy of CRRT in the management of severe PM/DM and its value as a good option for treatment of severe autoimmune disease, especially systemic inflammatory response syndrome.
