Comparison of temporomandibular joint injuries after three-dimensional conformal and intensity-modulated radiotherapies for nasopharyngeal carcinoma.
- Author:
Dongping CHEN
1
;
Yi YU
;
Bin QI
;
Jinquan LIU
;
Mingyi LI
;
Yuying LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma; Female; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; radiotherapy; Radiation Injuries; etiology; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal; adverse effects; methods; Radiotherapy, Intensity-Modulated; adverse effects; methods; Temporomandibular Joint; injuries
- From: Journal of Southern Medical University 2012;32(7):991-994
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the radiation injuries of the temporomandibular joint (TMJ) following three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC).
METHODSThirty-nine NPC patients without previous radiotherapy underwent 3D-CRT and another 32 received IMRT in our institute. The distance between the 2 dens incisivus medialis (DDIM) and LENT SOMA criteria were employed to evaluate TMJ injuries, clinical outcomes, and the performance-to-price ratios.
RESULTSThe short-term local response rates were similar between the two groups (P=0.878). The mean radiation doses of the TMJ were significantly higher in 3D-CRT group than in IMRT group (57.06 vs 40.90 Gy, P<0.001). The DDIM showed significant changes in 3D-CRT groups after the radiotherapy (P<0.05). No significant difference was found in the TMJ injuries between the two groups according to the SOMA criteria (P>0.05).
CONCLUSIONRadiation injuries of the TMJ are tolerable in both 3D-CRT and IMRT groups, and 3D-CRT is a more economic choice for patients who can not afford IMRT.
