Impact of cytomegalovirus infections on T lymphocyte subsets in children with β-thalassemia major early after allogeneic hematopoietic stem cell transplantation.
- Author:
Yanhua WANG
1
;
Xuedong WU
;
Xiaoqin FENG
;
Yuelin HE
;
Fuyu PEI
;
Chunfu LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; CD8-Positive T-Lymphocytes; immunology; Child; Child, Preschool; Cytomegalovirus; Cytomegalovirus Infections; immunology; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Postoperative Period; T-Lymphocyte Subsets; beta-Thalassemia; immunology; surgery; virology
- From: Journal of Southern Medical University 2012;32(7):1008-1011
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of human cytomegalovirus (HCMV) infection on T lymphocyte subsets in children with β-thalassemia major (TM) during the initial 6 months after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).
METHODSFrom January, 2010 to January, 2011, 35 children with TM underwent Allo-HSCT. Peripheral blood samples were obtained from the children 6 month after the transplantation to examine the changes of T lymphocytes subsets in relation to HCMV seropositivity.
RESULTSThirteen children were found seropositive and 22 were seronegative for HCMV. The HCMV-seropositive children had a higher CD8⁺ cell percentage but a lower CD4⁺ cell percentage than those without HCMV infection. Compared with those seronegative for HCMV, the children with HCMV seropositivity showed increased percentages of CD8⁺ cells and CD8⁺CD28⁻ cells with a decreased percentage of CD8⁺CD28⁺ cells. A positive linear correlation was found between the percentages of CD8⁺CD28⁻ cells and CD8⁺ cells.
CONCLUSIONHCMV infection can lead to the accumulation of CD8⁺CD28 cells to cause increased CD8⁺ T cells in the peripheral blood in TM children after Allo-HSCT. The percentages of CD8⁺CD28⁻ cells has a positive linear correlation to that of CD8⁺ cells.
