Clinical and pathologic characteristics of primary angiosarcoma of breast.
- Author:
Hong LIU
1
;
Jing ZHAO
;
Yu FAN
;
Xi-lin FU
;
Li FU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antigens, CD34; metabolism; Breast; metabolism; pathology; surgery; Breast Neoplasms; metabolism; pathology; surgery; Breast Neoplasms, Male; metabolism; pathology; surgery; Diagnosis, Differential; Female; Follow-Up Studies; Hemangiosarcoma; metabolism; pathology; surgery; Humans; Immunohistochemistry; Male; Mastectomy; methods; Middle Aged; Platelet Endothelial Cell Adhesion Molecule-1; metabolism; von Willebrand Factor; metabolism
- From: Chinese Journal of Pathology 2006;35(10):598-601
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical and pathologic characteristics of primary angiosarcoma of breast.
METHODSFive cases of primary angiosarcoma of breast were reviewed. Immunohistochemical study (SP method) for factor VIII-related antigen, CD31, CD34, estrogen receptor, progesterone receptor and c-erbB-2 was performed. The clinical data were also analyzed.
RESULTSAll of the 5 patients had a history of a painless breast lump. Ultrasound examination and mammogram did not reveal any specific findings. Histologically, various degree of cellular pleomorphism was noted. Immunohistochemical study showed a positive expression of endothelial associated antigens of the tumors cells in all the 5 cases. The staining result for estrogen receptor, progesterone receptor and c-erbB-2 was negative.
CONCLUSIONSPrimary angiosarcoma of breast is a rare entity. The diagnosis is rather difficult owing to the lack of specific clinical findings and histological heterogeneity. Application of Positive expression of endothelial associated antigens of the tumors cells is helpful in making a pathological diagnosis morphologically.
