Protective effect of estrogen against chemotherapy-induced ovarian damage in rats.
- Author:
Li-ping HAN
1
;
Yuan-li HE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclophosphamide; adverse effects; Estradiol; blood; therapeutic use; Female; Follicle Stimulating Hormone; blood; Ovary; drug effects; pathology; Primary Ovarian Insufficiency; chemically induced; prevention & control; Random Allocation; Rats; Rats, Wistar
- From: Journal of Southern Medical University 2009;29(5):872-875
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effect of estrogen against cyclophosphamide (CTX)-induced ovarian failure in female rats.
METHODSSixty female Wistar rats (2-3 months old) were randomized into 4 groups to receive treatments with normal saline, CTX, estradiol (E2) or CTX+E2. Serum estradiol and follicle-stimulating hormone (FSH) concentrations were measured regularly in the 4 groups, and the weight of the ovary and uterus, follicle number and mean diameter of the follicles were compared.
RESULTSCompared with CTX+EE2 group, the CTX group showed significantly increased FSH levels and decreased EE2 levels (P<0.05). The weight of the ovary and uterus and follicle number were significantly lower in CTX group than in CTX+EE2 group (P<0.05). No obvious differences in the indexes were found between the control and CTX+E2 groups.
CONCLUSIONEstrogen administration provides protection against CTX-induced ovarian damage in rats.
