Expressions of proliferating cell nuclear antigen, Bcl-2, and Bax in lymphocytes of patients with oral lichen planus.
- Author:
Lei LEI
1
;
Wei-xia TAN
;
Miao YU
;
Xu-long ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Humans; Lichen Planus, Oral; metabolism; Lymphocytes; metabolism; Male; Middle Aged; Mouth Mucosa; metabolism; Proliferating Cell Nuclear Antigen; metabolism; Proto-Oncogene Proteins c-bcl-2; metabolism; bcl-X Protein; metabolism
- From: Journal of Southern Medical University 2009;29(5):946-948
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of proliferating cell nuclear antigen (PCNA), B cell lymphoma-2 (Bcl-2) and Bcl-associated X (Bax) in the lymphocytes of patients with oral lichen planus (OLP).
METHODSImmunohistochemistry was used for detecting the expressions of PCNA, Bcl-2 and Bax proteins in oral lichen planus tissue and normal oral mucosa (NOM).
RESULTSThe expressions of PCNA and Bcl-2 proteins increased significantly in the lymphocytes of patients with OLP compared with those in NOM. The expressions of PCNA and Bcl-2 proteins showed no significant differences between patients with OLP of general type and erosive type.
CONCLUSIONIncreased expression of PCNA and the imbalance of Bcl-2/Bax expressions in the lymphocytes of patients with OLP can be important causes for continuous lymphocyte infiltration in OLP.
