Expression of annexin V in decidua tissues of preeclampsia patients.
- Author:
Ya-Ling FENG
1
;
Chang-Ju ZHOU
;
Min XUE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Annexin A5; metabolism; Case-Control Studies; Decidua; metabolism; Female; Humans; Immunohistochemistry; Pre-Eclampsia; metabolism; pathology; Pregnancy; RNA, Messenger; genetics
- From: Journal of Southern Medical University 2009;29(7):1438-1441
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of annexin V in the decidua tissues of preeclampsia patients and explore its clinical significance.
METHODSReal-time PCR, Western blotting and immunohistochemistry were employed to detect the mRNA and protein expressions of annexin V in the deciduas from 35 normal pregnant women at full term, 38 early onset severe preeclampsia patients and 33 late onset severe preeclampsia patients.
RESULTSAnnexin V was found on the cell membrane and in the cytoplasm of the decidual cells and stroma. Both the mRNA and protein of annexin V expressions in the decidua tissues were significantly different between normal pregnancy group and early or late onset severe preeclampsia group (P<0.05), being the highest in normal pregnancy group and the lowest in early onset severe preeclampsia group.
CONCLUSIONThe low expression of annexin V in the deciduas might participate in the hypercoagulability state in preeclampsia patients.
