The expression of CEACAM-1 and CXCL-14 in infantile hemangioma.
- Author:
Guang-Qi XU
1
;
Ren-Rong LÜ
;
Ran HUO
;
Xuan GUO
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD; metabolism; Cell Adhesion Molecules; metabolism; Chemokines, CXC; metabolism; Child; Child, Preschool; Female; Hemangioma; metabolism; pathology; Humans; Infant; Male
- From: Chinese Journal of Plastic Surgery 2010;26(3):195-198
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expression of CEACAM-land CXCL-14 in the different stages of infantile hemangioma and to explore the role of CEACAM-1 and CXCL-14 in the occurrence and development of infantile hemangioma.
METHODSThe expression of CEACAM-1 and CXCL-14 was detected by immunohistochemical technique and Western Blot in cases of proliferating hemangiomas, involuting hemangiomas, involuted hemangiomas. The mean optical density was measured by image analysis system.
RESULTSThe expression of CEACAM-1 in early stage of proliferating hemangiomas was weak or negative, while it was strong in involuting hemangiomas and positive in the involuted stage. The differences between different stages had a statistically significance (P < 0.05). The expression of CXCL-14 was weak or negative in stage of proliferating hemangiomas, positive in involuting hemangiomas and strong in the involuted stage. The differences between different stages had a statistically significance (P < 0.05).
CONCLUSIONSCEACAM-1 and CXCL-14 are involved in the occurrence and development of infantile hemangioma.
