Effect of botulinum toxin type A injection into the masseter muscle on mandibular development in rats.
- Author:
Jin-Jun HUANG
1
;
Da-Lie LIU
;
Bing CHEN
;
Jin-Huang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Botulinum Toxins, Type A; administration & dosage; pharmacology; Injections, Intramuscular; Male; Mandible; drug effects; growth & development; Masseter Muscle; Rats; Rats, Wistar
- From: Chinese Journal of Plastic Surgery 2010;26(4):280-285
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Botulinum toxin type A (Botox) injection into the masseter muscle on mandibular development in rats.
METHODS12 28-day-old Wistar rats were divided into two groups as Botox group (n= 6) and control group (n = 6) which received anesthesia only. In Botox group, Botox was injected into the right masseter muscle, while only sterile saline into the left muscle. When the rats were 75-day-old, CT scan and 3D reconstruction were performed for cephalometry. The masseter muscles at both sides were weighed. Histologic study of masseter muscle and mandible was also performed.
RESULTSThe weight of right masseter muscle was (0.4575 +/- 0.0940) g in Botox group, and (0.8899 +/- 0.1030) g in control group (< 0.05). The mandibular height II and III was (10.8 +/- 0.8) mm and (9.5 +/- 0.6) mm in Botox group and (12.5 +/- 0.6) mm and (10.7 +/- 0.4) mm in control group, respectively (P < 0.05). The intergonial distance was (11.6 +/- 0.6) mm and (12.4 +/- 0. 6) mm in Botox and control group, respectively (P > 0.05).
CONCLUSIONSWhen the rats receive Botox injection into the masseter muscle at young age, the grown-up rats have a decreased mandibular height, but the mandibular length and intergonial distance are not affected.
