Expression of estrogen sulfotransferase in the mammary gland of hypertrophic breast and its significance.
- Author:
Yan-qing YANG
1
;
Jia-ming SUN
;
Qiong LI
;
Rui-rui ZHANG
;
Ke GUO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Breast; abnormalities; enzymology; Case-Control Studies; Female; Humans; Hypertrophy; enzymology; Mammary Glands, Human; enzymology; Middle Aged; Sulfotransferases; metabolism; Young Adult
- From: Chinese Journal of Plastic Surgery 2011;27(1):48-50
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of estrogen sulfotransferase (EST) in the mammary gland of hypertrophic breast and its significance.
METHODSEST expression in the mammary gland was detected by EnVision two step method of immunohistochemistry in 15 cases with normal breasts and 32 cases with hypertrophic breasts, including 19 gland-associated cases and 13 fat-associated cases.
RESULTSThe positive expression rate of EST in mammary gland was 34.4% (11/32) in hypertrophic group and 93.3% (14/15) in normal group, showing a significant difference between the two groups (P < 0.01). The positive expression rate of EST was 10.5% (2/19) in gland-associated group and 69.2% (9/ 13) in fat-associated group, showing a significant difference between the two groups (P < 0.01).
CONCLUSIONSDecrease or deletion of EST in the mammary gland may be related to the development of hypertrophic breast, especially gland-associated hypertrophic breast.
