Chemical constituents of Ligularia duciformis.
- Author:
Kai-Zhou FU
1
;
Neng-Jiang YU
;
Yang ZHANG
;
Yi-Min ZHAO
Author Information
1. College of Life Sciences, Ningxia University, Yinchuan 750021, China.
- Publication Type:Journal Article
- MeSH:
Asteraceae;
chemistry;
Magnetic Resonance Spectroscopy
- From:
Acta Pharmaceutica Sinica
2007;42(6):621-624
- CountryChina
- Language:Chinese
-
Abstract:
Ligularia duciformis is a plant of the Ligularia genus (Compositae) which has been reported to have therapeutic effects of treating diseases such as bronchitis and coughing. In order to find out the bioactive components, the 85% ethanol extract of the root and rhizome of L. duciformis was treated by solvents extraction and column chromatography on silica gel and Sephadex LH-20. Six compounds were obtained from the ethyl acetate fraction and identified as 3-methoxy-4-hydroxyphenylpropyl caffeate (I), 6beta, 8beta-dihydroxyeremophil-7 (11)-en-12, 8alpha-olide (II), 6beta, 8alpha-dihydroxyeremophil-7 (11)-en-12, 8beta-olide (III), 6beta-hydroxyeremophil-7 (11)-en-12, 8alpha-olide (IV), stigmasterol (V) and beta-daucosterol (VI) by analysis of their physic-chemical constants and spectral data. Compound I is a new compound and compounds II - V were isolated from L. duciformis for the first time. The antitussive effect of the compounds is under evaluation.
