Synthesis of derivatives of (9S) -9-hydroxyl-12-methylene erythromycin A and their antibacterial activity in vitro.
- Author:
Peng XU
1
;
Yao YANG
;
Yang SHI
;
Ping-Sheng LEI
;
Lu LIU
Author Information
1. Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
chemical synthesis;
chemistry;
pharmacology;
Erythromycin;
analogs & derivatives;
chemical synthesis;
chemistry;
pharmacology;
Microbial Sensitivity Tests;
Molecular Structure;
Staphylococcus aureus;
drug effects;
Staphylococcus epidermidis;
drug effects;
Streptococcus pneumoniae;
drug effects
- From:
Acta Pharmaceutica Sinica
2007;42(5):497-501
- CountryChina
- Language:Chinese
-
Abstract:
The derivatives of (9S)-9-hydroxyl-12-methylene erythromycin A were synthesized by using erythromycin A as a starting material. An intermediate (9S)-9,11-O-isopropylidene-6-O-allyl-2' ,4"-O-bis(benzoyl)-12,21-anhydro erythromycin A 12 was obtained. The antibacterial activity in vitro of two compounds, 6 and 11, was tested. The preliminary biological test showed that two compounds exhibited less potent antibacterial activity in vitro.
