Metabolism of trans-resveratrol-3-O-glucoside in vitro in rat tissues.
- Author:
Mao-Jin ZHOU
1
;
Xiao-Yan CHEN
;
Da-Fang ZHONG
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Duodenum;
metabolism;
Female;
Glucosides;
metabolism;
Ileum;
metabolism;
Intestinal Mucosa;
metabolism;
Intestine, Small;
metabolism;
Jejunum;
metabolism;
Liver;
metabolism;
Male;
Rats;
Rats, Wistar;
Stilbenes;
metabolism;
Stomach;
metabolism
- From:
Acta Pharmaceutica Sinica
2007;42(5):520-524
- CountryChina
- Language:Chinese
-
Abstract:
To study the metabolism of trans-resveratrol-3-O-glucoside (TRG) in vitro in rat tissues, the incubation with cell-free extracts from rat stomach, duodenum, jejunum, ileum and liver was performed, separately. After TRG was incubated with the tissue extracts at 37 degrees C for up to 90 min, the deglycosylation of TRG was (3.50 +/- 0.24) % for stomach, (65.7 +/- 5.94)% for duodenum, (83.5 +/- 6.43)% for jejunum, (77.6 +/- 6.26)% for ileum and (9.62 +/- 1.21)% for liver, separately. It was observed that the small intestine extracts were more active in deglycosylation of TRG than the liver extract, which suggested that the small intestine mucosa played an important role in deglycosylation of TRG. It was assumed that the deglycosylation of TRG was catalyzed by beta-glucosidase in small intestine mucosa.
