Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors.
- Author:
Ming-yan YU
1
;
Xin-yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
pharmacology;
HIV Long Terminal Repeat;
HIV-1;
genetics;
Humans;
I-kappa B Kinase;
metabolism;
I-kappa B Proteins;
metabolism;
NF-KappaB Inhibitor alpha;
NF-kappa B;
antagonists & inhibitors;
metabolism;
Nicotinic Acids;
pharmacology;
Nitriles;
pharmacology;
Transcription, Genetic;
drug effects;
Virus Replication
- From:
Acta Pharmaceutica Sinica
2007;42(10):1007-1012
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
