Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: Multicenter Study of 65 Cases.
10.3341/jkos.2009.50.3.390
- Author:
Jaeryung OH
1
;
Oh Woong KWON
;
Min Ho KIM
;
Jong In KIM
;
Ha Kyoung KIM
;
Hyung Chan KIM
;
Dong Heun NAM
;
Kyu Hyung PARK
;
Joon Hong SOHN
;
Boo Sup OUM
;
Seung Young YU
;
Young Hee YOON
;
Ill Han YOON
;
Hee Sung YOON
;
Jae Heung LEE
;
Jeong Hee LEE
;
Ji Eun LEE
;
Woo Hyok CHANG
;
Sung Won CHO
;
Hee Seung CHIN
;
Kuhl HUH
;
Hyung Woo KWAK
Author Information
1. Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
BCVA;
Chronic CSC;
CMT;
PDT
- MeSH:
Eye;
Female;
Follow-Up Studies;
Humans;
Korea;
Male;
Photochemotherapy;
Retrospective Studies;
Subretinal Fluid;
Tomography, Optical Coherence;
Triazenes;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2009;50(3):390-398
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine the effect of photodynamic therapy (PDT) on patients with chronic central serous chorioretinopahty (CSC). METHODS: This was a retrospective multicenter study. We collected demographic and ophthalmic data for patients with chronic CSC who were treated with PDT from 16 institutions in Korea. The best corrected visual acuity (BCVA), ophthalmoscopic finding and optical coherence tomography at baseline and follow-up visits were compared longitudinally. RESULTS: Sixty-five eyes of 65 patients were recruited. Males (51 patients, 78.5%) outnumbered females (14 patients, 21.5%). The mean age was 46.4+/-10.0 years of age (28~69). By 1 month, mean BCVA improved from 0.47 to 0.37 (logarithm of the minimum angle of resolution) (P <0.01). This BCVA increased throughout 6 months. Subretinal fluid resolved partially or completely in 89.1% of the patients. Central macular thickness (CMT) decreased from 303.4 to 168.7 micrometer. The amount of change in CMT after PDT was correlated to the female sex and prePDT CMT. At 3 months after PDT, the amount of change in BCVA was significantly related to that of change of CMT (p <0.05). Adverse events were reported in 4 cases, however, most were mild. CONCLUSIONS: PDT was effective and safe for treating chronic CSC.
