Incidence of coronary artery disease and outcome of patients with left ventricular noncompaction.
- Author:
Xiao-jin GAO
1
;
Lian-ming KANG
;
Jian ZHANG
;
Yong JIANG
;
Shi-hua ZHAO
;
Min-jie LU
;
Huai-bing CHENG
;
Xiao-liang LUO
;
Wen JIANG
;
Rong LÜ
;
Jie ZHU
;
Yue-jin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cardiomyopathies; complications; diagnosis; pathology; Female; Heart Ventricles; pathology; Humans; Incidence; Isolated Noncompaction of the Ventricular Myocardium; complications; diagnosis; pathology; Male; Middle Aged; Prognosis; Retrospective Studies; Young Adult
- From: Chinese Journal of Cardiology 2011;39(8):725-729
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the incidence of coronary artery disease (CAD) and outcome of patients with left ventricular noncompaction (LVNC).
METHODSFifty-one patients with LVNC evaluated by echocardiography and/or cardiac magnetic resonance (CMR) from January 2006 to August 2010 were retrospectively reviewed. Coronary angiography or MDCT was performed for detecting coronary artery disease. Predictors of the cardiac events were analyzed by Cox regression analysis.
RESULTSThere were 31 LVNC patients without CAD and 20 LVNC patients with CAD including single vessel coronary disease in 9 cases, double vessel coronary disease in 3 cases, three vessel coronary disease in 5 cases and left main coronary disease in 3 cases. Coronary artery bypass graft and percutaneous coronary intervention (PCI) were performed in 4 patients. Compared to LVNC patients without CAD, mean age (P = 0.008), incidence of hypertension (65.0% vs. 19.4%, P = 0.001), diabetes mellitus (40.0% vs. 12.9%, P = 0.026) and hyperlipidemia (55.0% vs. 25.8%, P = 0.035) were significantly higher while NT-proBNP level was significantly lower (P = 0.049) in LVNC patients with CAD. Incidence of major cardiac events was similar in LVNC patients with or without CAD. LogNT-proBNP is the independent prognostic factor for adverse cardiac events in patients with LVNC (HR 3.993, 95%CI 1.140 - 13.988, P = 0.030).
CONCLUSIONSCoronary artery disease is common in patients with LVNC and associated with traditional risk factors for CAD. Poor prognosis is associated with increased NT-proBNP but not with CAD in this patient cohort.
