Clinical and coronary angiographic features of patients with systemic vasculitis and coronary artery disease
10.3760/cma.j.issn.0253-3758.2011.08.010
- VernacularTitle:系统性血管炎合并冠心病患者的冠状动脉病变及临床特征
- Author:
Jing YANG
1
;
Dong XU
;
Zhu-Jun SHEN
;
Chong-Hui WANG
;
Shu-Yang ZHANG
;
Zhong-Jie FAN
;
Xiao-Feng JIN
;
Yong ZENG
;
Zhen-Yu LIU
;
Hong-Zhi XIE
;
Quan FANG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院
- Keywords:
Vasculitis;
Coronary disease;
Coronary angiography
- From:
Chinese Journal of Cardiology
2011;39(8):730-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical and coronary angiographic features of patients with systemic vasculitis and coronary artery disease. Method Fifteen patients ( 11 male) with systemic vasculitis and coronary artery diseases admitted to our hospital from January 1999 to October 2009 were reviewed. Results There were 6 patients with Behcet's disease, 3 patients with Churg-Strauss syndrome, 2 patients with Takayasu arteritis, 1 patient with polyarteritis nodosa, 1 patient with microscopic polyangiitis, 1 patient with Wegner's granulomatosis and 1 patient with Kawasaki disease. Mean age of this cohort was (39. 3 ± 11.9) years. Adverse coronary events occurred in 4 patients during the inactive phase of systemic vasculitis and in 9 patients during the active phase of systemic vasculitis. Twelve patients were hospitalized with acute myocardial infarction, 2 with angina pectoris and 1 with cardiac tamponade. There were 3 patients with acute left ventricular dysfunction and 3 patients with severe arrhythmias. Compared to patients in the inactive phase, patients in the active phase were younger [(32. 4 ± 8. 1 )years vs. (47.0 ± 10. 2)years],had less risk factors for atherosclerosis ( 1.2 ± 1. 5 to 2. 8 ± 1.7) and the time intervals between coronary artery disease and systemic vasculitis was shorter [0 -7 years( average 1.6 years) to 3 -30 years( average 17.7 years)]. Coronary angiography evidenced coronary stenosis or occlusions in 11 patients, coronary aneurysm and acute thrombosis in 1 patient, coronary aneurysms and occlusions in 1 patient and coronary spasm in 2 patients. LVEF measured by eehocardiography was less than 50% in 8 patients. Conclusion Patients with various systemic vasculitis could develop severe coronary artery disease due to coronary stenosis/occlusion, aneurysma, thrombosis and coronary spasm.
