Roles of monocyte chemoattractant protein-1, RANTES and Fractalkine on promoting vulnerability of atherosclerotic plaques
10.3760/cma.j.issn.0253-3758.2011.09.005
- VernacularTitle:趋化因子促进冠状动脉粥样硬化斑块不稳定的分子机制
- Author:
Tian-Jun QI
1
;
Wen-Qiang CHEN
;
Cui-Ling JIANG
;
Tian-Hao YANG
;
Mei-Qing ZHAI
;
Da-Qing LI
;
Bei-An YOU
;
Gui-Peng AN
;
Xiao-Bo HU
;
Yu-Guo CHEN
Author Information
1. 山东淄博矿业集团有限责任公司中心医院
- Keywords:
Atherosclerosis;
Chemotactic factors;
Ultrasonography,interventional
- From:
Chinese Journal of Cardiology
2011;39(9):797-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the roles of monocyte chemotactic factors ( MCP-1, RANTESand Fractalkine) on the vulnerability of atherosclerotic plaques in patients with stable (SAP) and unstable angina pectoris (UAP). Methods Patients with SAP (n =50) and UAP ( n =50) underwent coronary angiography (CAG) and intravenous ultrasound (IVUS) were included in the study. Monocyte chemotaxis was assayed by the transwell chamber. Concentrations of hs-CRP, MCP-1, RANTES and Fractalkine were measured by Enzyme-linked-immonosorbent assay ( ELISA ). mRNA expression of MCP-1, RANTES and Fractalkine in the monocytes was detected by RT-PCR. Results IVUS evidenced soft lipid plaques in 48％UAP patients and in 16％ SAP patients (P ＜ 0. 05). SAP patients had mainly fibrous and mixed plaques.Plaque burden and vascular remodeling index were significantly higher in UAP patients than in SAP patients (P ＜0. 01 ). The averaged number of migrated monocytes in the UAP patients were higher than that in patients with SAP (P ＜ 0.01 ). Concentration of hs-CRP, MCP-1, RANTES and Fractalkine were significantly higher in UAP patients than those of SAP patients ( P ＜0. 05 or P ＜0. 01 ). mRNA expression of MCP-1, RANTES and Fractalkine in patients with UAP was significantly higher than those of SAP patients ( P ＜ 0. 05 ). Conclusion Upregulated monocyte chemotactic factors ( MCP-1, RANTES and Fractalkine)might promote coronary plaque vulnerability in UAP patients.
