Pressure wave reflections and central blood pressure in treated hypertensive subjects
10.3760/cma.j.issn.0253-3758.2011.09.010
- VernacularTitle:接受降压治疗患者的压力波反射及中心动脉收缩压
- Author:
Wen-Kai XIAO
1
;
Ping YE
;
Lei-Ming LUO
;
De-Jun LIU
;
Hong-Mei WU
Author Information
1. 解放军总医院
- Keywords:
Hypertension;
Radial artery;
Elasticity;
Pressure wave reflections
- From:
Chinese Journal of Cardiology
2011;39(9):820-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences in pressure wave reflections and central blood pressure between brachial BP classification and the effect of antihypertensive drugs. Method In 1371chronically treated hypertensive subjects aged 33 -87 years [679 males and 692 females, mean age (47.2 ± 11.5 ) years], radial arterial augmentation index ( rAI ) and central systolic blood pressure were measured using an automated tonometric method. Results rA1 gradually increased from the subgroup with the lower blood pressure to the higher blood pressure ( P ＜ 0. 01 ), for each given brachial value, central systolic blood pressure was lower than the corresponding brachial pressure( P ＜0. 01 ). In multivariable linear regression models analysis revealed that the application of angiotensin converting enzyme inhibitor ([β =-0. 09, P ＜ 0. 05 ) , ATI receptor blockade ( β =-0. 07, P =0. 01 ), calcium channel blocker( [β =-0. 12,P ＜ 0. 01 ) and diuretic ( β =0. 14, P =0. 04 ) were independent determinants of rAI. Central SBP significantly correlated to the application of ACEI( β =- 0. 07, P =0. 02 ), ARB ( β =- 0. 08, P =0. 01 )and CCB( β =-0. 15, P ＜0. 05 ). Conclusions In chronically treated hypertensive individuals, tight blood pressure control would be effective in reducing the reflection wave and central BP. Antihypertensive treatment strategies with more beneficial effects on arterial properties are needed.
