Serum Lmmunoglobulin G and M Level after Xenograft Valve or Valved Conduit Implantation.
- Author:
Jae Gun KWAK
1
;
Jae Suk YOO
;
Sun Hee YOON
;
Woong Han KIM
;
Kyung Hwan KIM
;
Yong Jin KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Seoul National University, Seoul National University Hospital, Korea. kyj@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Xenograft;
Immune response;
Heart valve prosthesis;
Conduits
- MeSH:
Heart Valve Prosthesis;
Humans;
Immunoglobulin G;
Immunoglobulins;
Transplantation, Heterologous
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2008;41(2):223-228
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study is to confirm that peripheral blood sampling for measuring of serum immunoglobulin can predict immunological changes after xenograft implantation. MATERIAL AND METHOD: Between March 2006 and January 2007, 19 patients were enrolled (10 xenograft implantation group, 9 control group). Through 3 peripheral blood samples, we measured changes in serum immunoglobulin G and M levels preoperatively, and 2 and 10 days postoperatively. RESULT: In both groups, serum immunoglobulin levels showed similar changes-they decreased 2 days postoperatively, then increased up to the baseline levels 10 days postoperatively. However, this postoperative change of immunoglobulin G and M was not significantly different in absolute value or pattern between the 2 groups (Ig G; p-value=0.393, Ig M; p-value=0.193). CONCLUSION: We could not predict immunological changes after xenograft implantation by measuring serum immunoglobulin levels by simple blood sampling. Direct checking of alpha-Galactose antibody may confirm an immunological reaction after xenograft implantation.
