Value of cardiac magnetic resonance imaging for the diagnosis of cardiac amyloidosis
10.3760/cma.j.issn.0253-3758.2011.10.009
- VernacularTitle:心脏核磁共振在心肌淀粉样变中的诊断价值
- Author:
Kong-Bo ZHU
1
;
Zhong-Wei CHENG
;
Zhuang TIAN
;
Da-Chun ZHAO
;
Yong-Tai LIU
;
Xue LIN
;
Tai-Bo CHEN
;
Hong-Zhi XIE
;
Yong ZENG
;
Li-Gang FANG
;
Xiu-Chun JIANG
;
Quan-Cai CUI
;
Quan FANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院
- Keywords:
Cardiomyopathies;
Amyloidosis;
Magnetic resonance imaging;
Biopsy
- From:
Chinese Journal of Cardiology
2011;39(10):915-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical features and cardiac magnetic resonance imaging (CMR) characteristics of patients with endomyocardial biopsy (EMB)-proven cardiac amyloidosis (CA).Methods EMB proven CA patients underwent CMR examination from September 2006 to December 2010 were included.The findings of clinical manifestation,electrocardiogram,echocardiography and CMR were analyzed.Results Among the 18 patients with EMB verified CA,5 patients underwent CMR.All 5 patients had heart failure symptoms and electrocardiogram was abnormal.Echocardiogram showed concentric left ventricular hypertrophy,granular appearance of the myocardium,left atrial enlargement and moderate to severe left ventricular diastolic dysfunction.CMR revealed increased thickness of the left ventricular wall (especially at the inter-ventricular septum),enlarged bilateral auricle,restricted left ventricular filling with normal or mild to moderate reduced systolic function.Pleural and pericardial effusions were observed in 2 patients.Abnormal late gadolinium enhancement (LGE) was detected in all 5 patients.CMR revealed different patterns of LGE.Left ventricular global subendocardial delayed gadolinium enhancement or transmural delayed gadolinium enhancement were found,and patients also showed line-,granular- or patchylike enhancement.The degree and range of LGE paralleled the disease course and were consistent with electrocardiogram changes.Conclusions As a noninvasive diagnostic tool,CMR is valuable in the diagnosis of CA.For patients with clinical suspicion of CA,CMR could be a helpful diagnostic tool,especially in the hospitals where EMB is not available.
