Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion
10.3760/cma.j.issn.0253-3758.2011.10.015
- VernacularTitle:白藜三醇对猪急性闭塞冠状动脉侧支循环的影响
- Author:
Zhi-Rong WANG
1
;
Wu XU
;
Chao-Qun ZHANG
;
Wei XIE
;
Zhao-Feng ZHOU
;
Xiao-Feng ZHOU
;
Zhuo-Qi ZHANG
Author Information
1. 徐州医学院附属医院
- Keywords:
Myocardial infarction;
Ultrasonography,Doppler;
Collateral circulation;
Estrogens
- From:
Chinese Journal of Cardiology
2011;39(10):946-949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion.Methods Eighteen healthy pigs were randomly divided into 3 groups:resveratrol group,nitroglycerin group and control group.Animal model of acute coronary occlusion was established through PTCA method,and the blood flow spectrum in the left circumflex artery (LGX) was detected using intracoronary Doppler ultrasound.Results The average peak velocity (APV) in infarction correlation artery (IRA) was significantly decreased immediately after coronary occlusion [ (0.85 ± 0.25 ) cm/s vs.( 24.83 ± 3.43 ) cm/s,P ＜ 0.05 ].The APV remained unchanged during 0,30 and 60 minutes after the occlusion.Reversed or bidirectional blood flow was observed and the APV increased significantly [ (9.22 ± 0.80) cm/s vs.(0.84 ± 0.21 ) cm/s,(8.93 ± 1.28) cm/s vs.(0.86 ± 0.26 ) cm/s respectively,P ＜0.05] after the coronary injection of resveratrol (2 mg) or nitroglycerin (0.3 mg).There was no significant difference in peak APV between the resveratrol and nitroglycerin groups.The duration of increased APV was significantly longer in resveratrol group than that in nitroglycerin group [ (58.83 ±6.15)min vs.(21.80 ±5.79)min,P ＜0.05].Conclusions The collateral circulation after acute coronary occlusion was obviously insufficient in pigs.Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model.
