Long-term outcome analysis of patients underwent percutaneous coronary intervention with prior ischemic stroke
10.3760/cma.j.issn.0253-3758.2011.11.002
- VernacularTitle:有缺血性卒中史的冠心病患者经皮冠状动脉介入治疗的长期疗效
- Author:
Ye-Chen HAN
1
;
Shu-Yang ZHANG
;
Song-Bai LIN
;
Zhu-Jun SHEN
;
Zhong-Jie FAN
;
Chong-Hui WANG
;
Xiao-Feng JIN
;
Hong-Zhi XIE
;
Zhen-Yu LIU
;
Yong ZENG
;
Quan FANG
Author Information
1. 中国医学科学院北京协和医学院北京协和医院
- Keywords:
Cerebrovascular accident;
Angioplasty,transluminal,peroutaneous coronary;
Treatment outcome
- From:
Chinese Journal of Cardiology
2011;39(11):980-983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics and long-term outcomes of patients underwent percutaneous coronary intervention(PCI) with prior ischemic stroke.Methods A total of 2053 patients underwent PCI in Peking union medical college hospital from January 2003 to December 2007 were included in this analysis and patients were followed up to December 2009.End-point included all-cause mortality,cardiac death,stent thrombosis,target-lesion revascularization,myocardial infarction,re-cerebral infarction.Major bleeding events were recorded during follow-up.Results There are 1945 coronary heart disease patients were followed up and 222 patients with prior ischemic stroke.Compared patients without prior ischemic stroke,patients with prior ischemic stroke were older ( P = 0.000),had higher hypertension morbidity(P = 0.000 ),higher diabetes mellitus morbidity ( P = 0.005 ),higher incidence of multi-vessels disease( P = 0.000).During the follow-up of (35.0 ± 19.6) months,cardiac death rate( 8.5％ vs.3.9％,P=0.002)and re-cerebral infarction rate (5.8％ vs.1.4％,P=0.000) were higher in patients with prior ischemic stroke than patients without prior ischemic stroke.Dual antiplatelet therapy treatment time[ ( 13.77 ±11.33 ) months vs.( 13.94 ± 11.33 ) months,P = 0.986 ] and major bleeding events (5.8％ vs.3.6％,P =0.l00)were similar between the two groups and cerebral hemorrhage rate( 1.8％ vs.0.5％,P =0.028)were higher in patients with prior ischemic stroke than patients without prior ischemic stroke.Conclusion Patients with prior ischemic stroke were associated with increased rate of risk factors,multiple coronary artery disease,cardiac death and re-cerebral infarction and higher cerebral hemorrhage rate during follow-up despite similar dual-anti platelet therapy time.
