Relationship between EPHX2 gene polymorphism and essential hypertension in Kazaks and Hans in Xinjiang.
- Author:
Na LI
1
;
Li WANG
;
Hu DING
;
Zhong WANG
;
Dao-wen WANG
;
Yu-jun XU
;
Wang-qiang ZHANG
;
Jun-cang DUAN
;
Yue-hong WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; China; epidemiology; Epoxide Hydrolases; genetics; Gene Frequency; Genotype; Humans; Hypertension; epidemiology; genetics; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Cardiology 2011;39(12):1101-1104
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between rs751141 gene polymorphisms in EPHX2 gene and essential hypertension in Kazak and Han in Xinjiang.
METHODSA total of 267 essential hypertensive patients in Kazaks, 368 essential hypertensive patients in Hans, 284 normotensive controls in Kazaks and 348 normotensive controls in Hans were enrolled in this study. TaqMan assay was used to detect the rs751141 G/A gene polymorphisms of EPHX2 gene.
RESULTSThe rs751141 G/A genotype frequencies for GA + AA genotypes was 40.2 percent in essential hypertensive subjects and 52.0 percent in control subjects in Hans, respectively. The genotype frequencies were significant difference between the two groups in Hans in Xinjiang (P < 0.01). The rs751141G/A gene polymorphism had no significant difference between essential hypertensive patients and normotensive controls in Kazaks in Xinjiang (P > 0.05).
CONCLUSIONThe essential hypertension in Kazaks in Xinjiang is not associated with rs751141G/A gene polymorphism of EPHX2 gene, but the essential hypertension in Hans in Xinjiang is associated with rs751141G/A allele gene polymorphism of EPHX2 gene. A type of rs751141 allele gene polymorphism may be the independent protective factor of essential hypertension in Hans in Xinjiang.
