Impact of CACNA1C polymorphisms on antihypertensive efficacy of calcium channel blocker
10.3760/cma.j.issn.0253-3758.2012.01.002
- VernacularTitle:CACNA1C基因多态性与钙通道阻滞剂降压疗效的关系
- Author:
Qian SUN
1
;
Qing-Xian LI
;
Xi-Fa SONG
;
Song-Gui ZHENG
;
Feng YAN
;
Peng CHEN
;
Ji-Fei TANG
;
Yu-Xin NIU
;
Qi-Yu BAO
;
Guo-Qiang ZHANG
;
Yun-Liang HU
Author Information
1. 温州医学院附属第二医院
- Keywords:
Hypertension;
Polymorphism,single nucleotide;
Calcium channel blockers
- From:
Chinese Journal of Cardiology
2012;40(1):3-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between genetic polymorphisms of CACNA1C that encoded the alc subunit of the L-type calcium channel and the efficacy of calcium channel blocker (CCB,Nifedipine extended release tablet/20 mg/d)in essential hypertension(EH)patients of Han Chinese in Wenzhou.Methods For the enrolled 103 EH patients,Multiplex Polymerase Chain Reaction(Muhi PCR)and matrix assisted laser desorption ionization time of flight MS(MLD1-TOF MS)were performed to detect their genotypes(rs216008,rs1051375,rs2299661,rs10848683,rs215976),blood pressure(BP)after CCB monotherapy was compared among patients with different genotypes.Results(1)Blood pressure was significantly reduced in all patients post CCB(P ＜ 0.05 vs.pre-CCB).(2)Diastolic blood pressure reduction was more significant in subjects with rs2299661 C/C genotype(wild genotype)than in subjects with rs2299661C/G and rs2299661G/G genotype(mutational genotype)[(12.46 ± 7.91)mm Hg (1 mm Hg=0.133 kPa)vs.(7.22±8.01)mm Hgand(5.93 ± 9.77)mm Hg,P＜0.05].(3)Systolic blood pressure reduction was more significant in subjects with rs216008 C/C genotype(wild genotype)than in subjects with rs216008 C/T genotype(mutational genotype)[(20.60 ± 12.35)mm Hg vs.(13.62 ±10.21)mm Hg,P ＜0.05].(4)Blood pressure reduction was similar between subjects with genotype of rs1051375,rs10848683 and rs215976.Conclusion EH patients with wild genotype of rs2299661 and rs216008 in CACNA1 C are more likely to be responders of CCB monotherapy.
