Photo-degradation products of 1-1-(6-methoxy-2-naphthyl)ethyl-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide.
- Author:
Hong JIANG
1
;
Min SONG
;
Tai-jun HANG
;
Zheng-xing ZHANG
Author Information
1. Department of Pharmaceutical Analysis, China Pharmaceutical University, Nangjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
methods;
Fibrinolytic Agents;
chemistry;
Molecular Structure;
Photolysis;
Quality Control;
Spectrometry, Mass, Electrospray Ionization;
methods;
Tandem Mass Spectrometry;
methods;
Tetrahydroisoquinolines;
chemistry
- From:
Acta Pharmaceutica Sinica
2007;42(10):1078-1081
- CountryChina
- Language:Chinese
-
Abstract:
To study the photo-degradation products of 1-[1-(6-methoxy-2-naphthyl) ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (code designation: P91024). The chemical structures of the major photo-degradation products of P91024 were identified by HPLC-MS and spectroscopic methods, and their reference substances were also synthesized for confirmation. The three major photo-degradation products were identified to be N-(4-nitrobenzyl)-6,7-dimethoxyl-3, 4-dihydroisoquinoline bromide, 1-[1-(6-methoxyl-2-naphthyl) ethyl]-6, 7-dimethoxyl-1, 2, 3, 4-tetrahydroisoquinoline and 2-isopropyl-6-methoxyl-naphthalene, respectively.
