A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer.
- Author:
Ke LIU
1
;
Bin MA
;
Yong-dong WANG
;
Xiao-yan CHEN
;
Da-fang ZHONG
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Molecular Weight;
Pharmaceutical Preparations;
analysis;
Software;
Spectrometry, Mass, Electrospray Ionization;
methods
- From:
Acta Pharmaceutica Sinica
2007;42(10):1112-1114
- CountryChina
- Language:Chinese
-
Abstract:
Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0.7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from -22.4 x 10(-6) to 36. 1 x 10(-6), among them 90% of the drugs achieved a mass accuracy better than 10 x 10(-6). The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.
