Progress in the design of selective ATP-competitive kinase inhibitors.
- Author:
Xiao-qiang DENG
1
;
Ming-li XIANG
;
Ruo JIA
;
Sheng-yong YANG
Author Information
1. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Adenosine Triphosphate;
chemistry;
Binding, Competitive;
Drug Design;
Molecular Structure;
Protein Binding;
Protein Kinase Inhibitors;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2007;42(12):1232-1236
- CountryChina
- Language:Chinese
-
Abstract:
Kinases play crucial roles in the life of cell. Their functional abnormity usually leads to many human major diseases including tumors. The prospecting of ATP-competitive small-molecule kinase inhibitors targeting kinases of therapeutic interest has become the focus of researches. Due to the high conservation of the catalytic domain of kinases, the selectivity of kinase inhibitors is poor in general. However, along with the development of structural biology and computer-aided drug design, great progress in the research of selective, ATP-competitive kinase inhibitors has been achieved in recent years. In this account, the review has been made on the development of the design of selective kinase inhibitors.
