Synthesis and antitumor activity of anthracene-9-carbaldehyde amino-s-triazole Schiff-bases with side-chain of S-acetic acid.
- Author:
Guo-Qiang HU
1
;
Xiu-Li DONG
;
Song-Qiang XIE
;
Wen-Long HUANG
Author Information
1. Institute of Pharmacy, Henan University, Kaifeng 475001, China. hgqxy@sina.com.cn
- Publication Type:Journal Article
- MeSH:
Acetic Acid;
chemistry;
Animals;
Anthracenes;
chemistry;
Antineoplastic Agents;
chemical synthesis;
chemistry;
pharmacology;
CHO Cells;
Cricetinae;
Cricetulus;
HL-60 Cells;
Humans;
Leukemia L1210;
pathology;
Mice;
Molecular Structure;
Schiff Bases;
chemical synthesis;
chemistry;
pharmacology;
Triazoles;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2008;43(1):50-53
- CountryChina
- Language:Chinese
-
Abstract:
To find out a novel lead compound from heterocyclic amine Schiff bases for developing new antitumor agents, each of (4-amino-5-substituted-s-triazol-3-ylthio) -acetic acids 2a-j was condensed with anthracene-9-carbaldehyde to obtain Schiff-bases of [4-(anthracen-9-yl methylene) amino] -5-substituted-s-triazol-3-ylsulfanyl] -acetic acids 3a-j. The structures of new compounds synthesized were characterized by elemental analysis and spectral data, and in vitro antitumor activity was also evaluated against CHO, HL60 and L1210 cell lines by MTT assay.
