Preparation of tablets containing enteric-coated diclofenac sodium pellets.
- Author:
Xiao-Le QI
1
;
Jia-Bi ZHU
;
Sheng-Jun CHEN
Author Information
1. Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210038, China.
- Publication Type:Journal Article
- MeSH:
Acrylic Resins;
chemistry;
Anti-Inflammatory Agents, Non-Steroidal;
chemical synthesis;
Cellulose;
chemistry;
Diclofenac;
chemical synthesis;
Drug Carriers;
Drug Compounding;
methods;
Drug Delivery Systems;
Methacrylates;
chemistry;
Particle Size;
Polymers;
chemistry;
Solubility;
Tablets, Enteric-Coated;
chemistry
- From:
Acta Pharmaceutica Sinica
2008;43(1):97-101
- CountryChina
- Language:Chinese
-
Abstract:
Fluidized-bed manufactured enteric-coated diclofenac sodium pellets were compressed into tablets. The blend of two aqueous acrylic resins dispersion in different ratios, Eudragit NE30D and Eudragit L30D-55, were used to prepare enteric-coated diclofenac sodium pellets of different particle sizes and coating level. The cushioning pellets with different properties and these enteric-coated pellets were compressed into tablets in different proportions. The drug release of the tablets containing these pellets would be lower than 10% in 2 h in simulated gastric fluid, but reach (83 +/- 2.42)% in 1 h in simulated enteric fluid. The mixture of Eudragit NE30D and Eudragit L30D-55 could be used to prepare enteric pellets which are suitable for compression. The cushioning pellets which were composed of stearic acid/microcrystalline cellulose (4:1, w/w) could avoid rupture of the coating of pellets during the compression.
