Synthesis and biological activity of a series of benzopyran derivatives.
- Author:
Lei TANG
1
;
Yu-She YANG
;
Ru-Yun JI
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
3T3-L1 Cells;
Adipocytes;
drug effects;
Animals;
Benzopyrans;
chemical synthesis;
chemistry;
pharmacology;
Blood Glucose;
metabolism;
Cell Differentiation;
drug effects;
Diabetes Mellitus, Experimental;
blood;
Hypoglycemic Agents;
chemical synthesis;
chemistry;
pharmacology;
Mice
- From:
Acta Pharmaceutica Sinica
2008;43(2):162-168
- CountryChina
- Language:Chinese
-
Abstract:
Thirteen benzopyran derivatives were synthesized and their activity stimulating the differentiation of preadipocytes into adipocytes were evaluated with 3T3-L1 cells. Compound 8 was also tested for its hypoglycemic activity on db diabetes mice model. Results indicated that compounds 3, 8 and 11 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, and compound 8 can reduce the blood-sugar level of db diabetes mice dramatically.
