Pharmacokinetic parameter and residua of 63Ni-NiCl2 in rat.
- Author:
Zhan LI
1
;
Hao WANG
;
Wang-Suo WU
Author Information
1. School of Nuclear Science and Technology, Lanzhou 730000, China.
- Publication Type:Journal Article
- MeSH:
Administration, Oral;
Animals;
Area Under Curve;
Feces;
chemistry;
Female;
Hair;
metabolism;
Nickel;
pharmacokinetics;
urine;
Radioisotopes;
pharmacokinetics;
urine;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2008;43(2):224-226
- CountryChina
- Language:Chinese
-
Abstract:
Absorption distribution and excretion of 63Ni-NiCl2, administered orally to rats were studied by using liquid scintillation counting method. It was observed that the concentration-time curves in blood fitted the two compartment model of pharmacokinetics, Ka=6.18 h(-1), T(1/2)alpha =0.79 h, T(1/2)beta=40.68 h, CL =0.42 mL kg(-1) h(-1), Tmax =0.53 h, Cmax=24,987.75 min(-1) mL(-1), and Vd=0.016 L kg(-1). After rats were treated by 63Ni-NiCl2 for 15 days, in 22 tissues tested, the contents of 63Ni-NiCl2 in hair, hypothalamus, hypophysis, pancreas, small and large intestines were higher, and the residua of 63Ni-NiCl2 was not discovered in liver, kidney and heart. Radioactivity eliminated was 83.27% by urine and feces, 54.86% by urine, 28.41% by feces.
