Vitamin D receptor gene polymorphism is not associated with bone mineral density of pre-menopausal women in Guangzhou.
- Author:
Wen WU
1
;
Xi-mei ZHI
;
Dong-feng LI
;
Kai LIN
;
Ling XU
;
Yan-hong YANG
Author Information
- Publication Type:Journal Article
- MeSH: Absorptiometry, Photon; Adult; Analysis of Variance; Bone Density; China; Female; Gene Frequency; Genotype; Humans; Middle Aged; Osteoporosis; genetics; metabolism; Polymorphism, Genetic; Premenopause; Receptors, Calcitriol; genetics
- From: Journal of Southern Medical University 2007;27(3):364-366
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the prevalence of vitamin D receptor (VDR) gene polymorphism in pre-menopausal women in Guangzhou and study its relationship with bone mineral density(BMD).
METHODSThe genotypes of VDR gene in 193 per-menopausal women in Guangzhou were analyzed by polymerase chain reaction-restriction fragment length polymorphism. BMD of the lumbar spine, femoral neck, greater trochanter and Ward's triangle were measured by dual-energy X-ray absorptiometry.
RESULTSIn the 193 subjects, 120 (66.2%) were identified as VDR bb genotype, 64 (33.2%) as Bb, and 9 (4.6%) as BB. The b allele frequencies reached 78.76%, and B allele frequencies was 21.24%. The distribution followed the Hardy-Weinberg equilibrium. No significant difference was found in BMD among the subjects with different genotypes.
CONCLUSIONVDR genotype is not related to BMD, and VDR polymorphism can not be used as a genetic marker for predicting the risk of osteoporosis in pre-menopausal women in Guangzhou.
